具有遗传性疾病和性状的遗传位点分析

随着信息技术的进步和发展,现代生物学越来越多地将这些技术用于大规模生物数据的收集、分析、挖掘等过程.大量计算机技术,特别是统计方法被用来进行复杂疾病的分析.大量研究表明,人体的许多表型性状差异以及对药物和疾病的易感性等都可能与某些位点相关联,或和包含有多个位点的基因相关联.因此,定位与性状或疾病相关联的位点在染色体或基因中的位置,能帮助研究人员了解性状和一些疾病的遗传机理,也能使人们对致病位点加以干预,防止一些遗传病的发生.利用随机森林方法、Bootstrap重抽样、logistic回归等大数据分析方法,意在解决优化生物学位点关联性分析中单一致病位点识别、多位点相互作用和多性状位点关联性分析等子问题.     

股票市场的长记忆及其动态结构

本文提出了结合平均小波系数法和自回归原始自助法的稳健长记忆检验,蒙特卡罗模拟显示该方法对于短期记忆过程具有稳定性。基于该方法对2005年4月8日至2015年6月30日的中国、美国、香港和德国股市进行了实证分析。全局检验结果表明仅中国的股票市场存在显著的长记忆,并且风险因素无法对长记忆解释,而美国、德国和香港的股市不存在长记忆。基于递增窗口的动态Hurst指数分析显示,金融危机时期4个股市都存在显著的长记忆。2010年后,除中国股市外,其余三个股市几乎不存在长记忆现象。     

A failure of a class of K-BKZ equations based on principal stretches

The invariants in the K-BKZ constitutive equation for an incompressible viscoelastic fluid are usually taken to be the trace of the Finger strain tensor and its inverse. The basis for this choice of invariants is not derived from the K-BKZ theory, but rather is due to the perception that this is the most natural choice. Research into using other sets of invariants in the K-BKZ equation, such as the principal stretches or the eigenvalues of the Finger strain tensor (i.e., the squares of the principal stretches) is relatively new. We attempt here to derive a K-BKZ equation based on the squares of the principal stretches that models the behavior of a low-density polyethylene melt in simple shear and uniaxial elongational deformation. In doing so, two assumptions are made as to the form of the strain-dependent energy function: first, that there is a function f(q) such that the energy function can be written as the sum of f(q _i ),i = 1, 2, 3, where the q _i 'sare the squares of the principal stretches, and second that f is a power law. We find that the K-BKZ equation resulting from these two assumptions is inadequate to describe both the shear and elongational behavior of our material and we conclude that the second of the above assumptions is not valid. Further investigation, including predictions of the second normal stress difference and some finite element calculations reveals that the first assumption is also invalid for our material.     

Eulerian spatial and temporal autocorrelations: assessment of Taylor's hypothesis and a model

We present measurements of Eulerian longitudinal velocity autocorrelations in homogeneous, isotropic, high-intensity (～9%) free-stream turbulence behind an active grid. Spatial correlations are measured using particle image velocimetry as well as with two-point hot-wire anemometry (HWA), while temporal correlations are measured using HWA. The temporal correlations are transformed into spatial correlations by using Taylor's ‘frozen’ hypothesis with both the mean as well as instantaneous velocities. A model relating Eulerian spatial and temporal autocorrelations is also used for this purpose. The differences from the measured spatial correlation resulting from the use of Taylor's hypothesis on the temporal correlation is quantified; even at this moderately high level of turbulent intensity, the result from the use of the instantaneous velocity as convection velocity is practically indistinguishable from that obtained using the mean velocity. Use of the model produces a good agreement between the estimates of the spatial correlation function. A relation between Eulerian spatial and temporal integral scales is also derived.     

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Homogeneity of variance and correlation coefficients is one of assumptions in the analysis of longitudinal data.However, the assumption can be challenged. In this paper, we mainly propose and analyze nonlinear mixed effects models for longitudinal data with exponential correlation covariance structure, intend to introduce Huber's function in the log likelihood function and get robust estimation (M-estimation) by Fisher scoring method. Score test statistics for homogeneity of variance and correlation coefficient based on M-estimation are then studied. A simulation study is carried to assess the performance of test statistics and the method we proposed in the paper is illustrated by an actual data example.     

Is the US stock market becoming weakly efficient over time? Evidence from 80-year-long data

We propose a degree of market efficiency in terms of entropy concepts. The relative efficiency for the US stock market varies over time from 1929 to 2012, with a slight decline in the past 10 years.     

Importance of verifying queue model assumptions before planning with simulation software

This case study uses empirical data gathered at an Australian refinery to verify the assumptions for queue distributions before using special-purpose software to plan the off-road-truck hauling of titanium dioxide to a refinery (n = 773). Easy-to-use spreadsheet software is utilized to verify assumptions for queue models. Managers are able to make decisions based on economic implications of queue models to avoid making costly planning mistakes. Analysts can use nonparametric hypothesis-testing techniques to verify distribution assumptions for optimization without having to write hard-to-maintain and complex algebraic linear equations or nonlinear search routines.     

扭转变形平面假设的讨论

在对圆轴扭转平面假设的内涵进行分析的基础上, 关联其在应力分析中 的应用, 并讨论了平面假设成立的条件以解释矩形截面翘曲现象, 可作为该部分课堂教学的 参考材料.